01Tissue repair
A foundational review of how paracrine signaling may influence tissue repair and regeneration.
Cell paracrine actions and tissue regeneration
Baraniak PR & McDevitt TC. Regenerative Medicine. 2010.
View original publicationEvidence & education
Research Studies
Explore peer-reviewed publications that have helped shape scientific inquiry in regenerative medicine.
Selected literature
Research across a developing field
Advances in biomedical science continue to expand research into regenerative cells, signaling, tissue repair, and immune modulation.
The studies below span laboratory research, animal models, early clinical investigations, and peer-reviewed reviews. They are presented as educational resources so clinicians can examine the original publications directly.
Study library
Pivotal publications
Select any publication to review its abstract or full journal record at the original source.
02Osteoarthritis
A proof-of-concept clinical trial evaluating intra-articular mesenchymal cell injection in knee osteoarthritis.
Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee
Jo CH et al. Stem Cells. 2014.
View original publication03Heart disease
An early randomized trial comparing allogeneic and autologous bone-marrow-derived mesenchymal cells in ischemic cardiomyopathy.
Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells
Hare JM et al. JAMA. 2012.
View original publication04Lupus
A multicenter clinical study examining safety and clinical response following umbilical-cord-derived mesenchymal cell transplantation in active, refractory lupus.
Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus
Wang D et al. Arthritis Research & Therapy. 2014.
View original publication05Parkinson’s disease
An open-label study exploring the feasibility and medium-term observations of autologous bone-marrow-derived mesenchymal cell transplantation.
Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson’s disease
Venkataramana NK et al. Translational Research. 2010.
View original publication06Rheumatoid arthritis
A clinical study evaluating the safety and efficacy of human umbilical-cord-derived mesenchymal cell therapy in active rheumatoid arthritis.
Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis
Wang L et al. Stem Cells and Development. 2013.
View original publication07Immunomodulation
An in-vitro study comparing the immunologic behavior of human umbilical cord perivascular cells with bone-marrow-derived stromal cells.
In vitro immunologic properties of human umbilical cord perivascular cells
Ennis J et al. Cytotherapy. 2008.
View original publication08Diabetes research
A preclinical study examining whether mesenchymal cells could influence autoimmune diabetes in a mouse model through regulatory T-cell activity.
Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells
Madec AM et al. Diabetologia. 2009.
View original publication09Infectious disease
A review of antimicrobial properties reported in mesenchymal cell research and the potential relevance to infection-focused investigation.
Antimicrobial properties of mesenchymal stem cells: therapeutic potential for cystic fibrosis infection and treatment
Sutton MT et al. Stem Cells International. 2016.
View original publication10Organ transplant
A small clinical protocol examining pretransplant autologous mesenchymal stromal cell infusion and immunoregulation in kidney transplantation.
Mesenchymal stromal cells and kidney transplantation: pretransplant infusion protects from graft dysfunction while fostering immunoregulation
Perico N et al. Transplant International. 2013.
View original publicationImportant context
Research is not a product claim.
These independent publications concern specific cell types, research methods, and investigational settings. They do not establish that a BioGenix product is approved to diagnose, treat, cure, or prevent any disease. Clinical decisions should be based on applicable law, product information, and a qualified provider’s independent judgment.
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